NeuroMab™ Rat Anti-Sortilin / NT3 Monoclonal Antibody (CBP2457)

Product Overview

Description

Sortilin was originally purified from human brain tissue and was identified as a new lipoprotein receptor, which was later identified as a multifunctional sorting receptor of the VPS10P-domain receptor family. Although Sortilin is predominately expressed in neurons of the central and the peripheral nervous systems, it is also expressed in metabolic tissues including liver. Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is critical for lipid metabolism, and it has been implicated in lipid disorders. Sortilin is also an APOE receptor implicated in Alzheimer disease.

Immunogen

Human SORT1 recombinant protein (327-638 a.a.) expressed in E. coli.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP2457

Applications

WB; IHC-P

Application Notes

WB (1.0-5.0 µg/mL); iHC-P (1.0-5.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1798

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

SORT1

Official Name

SORT1

Full Name

Sortilin

Alternative Names

SORT1; Gp95; LDLCQ6; NT3; NTR3; Sortilin 1

Gene ID

6272(Human); 20661(Mouse); 83576(Rat)

Uniprot ID

Q99523(Human); Q6PHU5(Mouse); O54861(Rat)

References

1. Skeldal S, et al. 2012. J. Biol. Chem. 287:43798-809.
2. Herda S, et al. 2012. Immunity. 37:854-66.
3. Gao A, et al. 2017. DNA Cell Biol. 36:1050-1061.
4. Carlo AS. 2013. Prion. 7:378-82.

Publications