Product
NeuroMab™ Rat Anti-Sortilin / NT3 Monoclonal Antibody (CBP2457)
[CAT#: NAB2010555LS]
Anti-Sortilin / NT3 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human; Rat
- Applications:
- WB; IHC-P
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Sortilin was originally purified from human brain tissue and was identified as a new lipoprotein receptor, which was later identified as a multifunctional sorting receptor of the VPS10P-domain receptor family. Although Sortilin is predominately expressed in neurons of the central and the peripheral nervous systems, it is also expressed in metabolic tissues including liver. Sortilin functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Sortilin is critical for lipid metabolism, and it has been implicated in lipid disorders. Sortilin is also an APOE receptor implicated in Alzheimer disease.
Immunogen
Human SORT1 recombinant protein (327-638 a.a.) expressed in E. coli.
Species Reactivity
Human; Rat
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a, κ
Clone Number
CBP2457
Applications
WB; IHC-P
Application Notes
WB (1.0-5.0 µg/mL); iHC-P (1.0-5.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1798
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
Batch Dependent
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Endotoxin Level
Low Endotoxin
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Skeldal S, et al. 2012. J. Biol. Chem. 287:43798-809.
2. Herda S, et al. 2012. Immunity. 37:854-66.
3. Gao A, et al. 2017. DNA Cell Biol. 36:1050-1061.
4. Carlo AS. 2013. Prion. 7:378-82.
2. Herda S, et al. 2012. Immunity. 37:854-66.
3. Gao A, et al. 2017. DNA Cell Biol. 36:1050-1061.
4. Carlo AS. 2013. Prion. 7:378-82.
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
