NeuroMab™ Anti-TASK1 potassium channel BBB Shuttle Antibody, Clone N374/48

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNK3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 251-411 (cytoplasmic C-terminus) of rat Acid-sensitive potassium channel protein TASK or TASK1 (also known as Potassium channel subfamily K member 3, TWIK-related acid-sensitive K(+) channel 1, Two pore potassium channel KT3.1, Cardiac two pore background K(+) channel, KCNK3 and cTBAK-1, accession number O54192)
Mouse: 96% identity (156/161 amino acids identical)
Human: 76% identity (163/161 amino acids identical)
<30% identity with TASK3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

N374/48

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with TASK3

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNK3

Official Name

KCNK3

Full Name

TASK1 K+ channel

Alternative Names

KCNK3; K2p3.1; OAT1; PPH4; TASK; TASK-1; TBAK1; potassium two pore domain channel subfamily K member 3; TASK1

Uniprot ID

O54912

Product Pictures

Fig. 1 Immunoblot versus crude membranes from adult rat brain (RBM) and wild-type (WT) and TASK1 KO mouse brains probed with N374/48 (left) and N52A/42 (right) TC supe.