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Creative Biolabs

NeuroMab™ Mouse Anti-S. Pyogenes CRISPR (CBP4382)

[CAT#: NAB2101175LS]

Anti-CRISPR (CAS9) Monoclonal Antibody

Host Species:
Mouse
Species Reactivity:
S. Pyogenes
Applications:
ICC; WB; IP

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Product Overview

Description

Cas9 is an RNA-guided DNA endonuclease enzyme associated with the CRISPR (Clustered Regularly Interspersed Palindromic Repeats) adaptive immunity system in Streptococcus pyogenes, among other bacteria. Cas9 interrogates and cleaves foreign DNA, such as invading bacteriophage DNA or plasmid DNA. Cas9 performs this interrogation by unwinding foreign DNA and checking if it is complementary to the 20 basepair spacer region of the guide RNA. If the DNA substrate is complementary to the guide RNA, Cas9 cleaves the invading DNA. In this sense, the CRISPR-Cas9 mechanism has a number of parallels with the RNA interference (RNAi) mechanism in eukaryotes.

Immunogen

Recombinant S. pyogenes Cas9 Protein (N-terminal 250 amino acids) expressed in E. coli.

Species Reactivity

S. Pyogenes

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP4382

Applications

ICC; WB; IP

Application Notes

ICC ( 1.0-10 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration
Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.
Target

Target

CRISPR (CAS9)

Official Name

CRISPR

Full Name

Clustered regularly interspaced short palindromic repeats

Alternative Names

Clustered regularly interspaced short palindromic repeats; CRISPR
Publications

Publications (0)

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