NeuroMab™ Rabbit Anti-LRRK2 Monoclonal Antibody (CBP4406)

Product Overview

Description

It is a rabbit monoclonal to LRRK2.

Expression Host

Mammalian cells

Immunogen

A synthesized peptide derived from human LRRK2

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

Rabbit

Isotype

IgG

Clone Number

CBP4406

Applications

IP; IF; IHC; ICC; WB

Application Notes

WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:50-1:200; IP: 1:50

Relevant Diseases

Parkinson's Disease

Research Areas

Neurogenesis; Neural Signal Transduction

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 2325

Product Properties

Form

Liquid

Formulation

Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Preservatives

Yes

Purification

Affinity-chromatography

Purity

>95%, as determined by SDS-PAGE

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

LRRK2

Official Name

LRRK2

Full Name

Leucine-rich repeat kinase 2

Alternative Names

LRRK2; AURA17; DARDARIN; PARK8; RIPK7; ROCO2; leucine-rich repeat kinase 2; leucine rich repeat kinase 2

Gene ID

120892(Human); 66725(Mouse); 300160(Rat)

Uniprot ID

Q5S007(Human); Q5S006(Mouse)

References

1. Hui, K. Y., Fernandez-Hernandez, H., Hu, J., Schaffner, A., Pankratz, N., Hsu, N. Y., ... & Peter, I. (2018). Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease. Science translational medicine, 10(423).

Publications