Mouse Anti-Aldolase C: C-terminus specific Monoclonal Antibody (CBP6668)
[CAT#: NAB2007FY1529]
Mouse Monoclonal to Aldolase C: C-terminus specific.
- Host Species:
- Mouse
- Species Reactivity:
- Human; Rat; Dog; Cow
- Applications:
- WB; IF; IHC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Aldolase is an important glycolytic cytoplasmic enzyme that can catalyze the reversible conversion of fructose 1,6-diphosphate to glyceraldehyde 3-phosphate. There are three aldolase isoenzymes coded by three different genes in mammals, namely aldolase A, B and C. Aldolase A is abundantly expressed in muscle enzymes, and aldolase B is expressed abundantly in the liver, which is regarded as a liver-specific enzyme (1-5). In adults, aldolase C is a brain-specific isoenzyme expressed in astrocytes and several types of neurons, especially Purkinje cells (4). Therefore, appropriate aldolase C antibodies can be used to identify astrocytes in cell cultures and slice materials, and the enzyme may be overexpressed in some forms of cancer (6). Recent studies have also shown that the detection of aldolase C in the blood may be a useful biomarker for the severity and recovery process of patients with sequelae of traumatic brain injury (7).
Immunogen
The C-terminal sequence in NCBI sequence 1XFB_A KYEGSGEDGGAAAQSLYIANHAY 342-364
Species Reactivity
Human; Rat; Dog; Cow
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1
Clone Number
CBP6668
Applications
WB; IF; IHC
Application Notes
WB: 1:1000
IF/IHC: 1:500-1:1000
IF/IHC: 1:500-1:1000
Product Properties
Form
Liquid
Formulation
50% PBS, 50% glycerol
Preservatives
5mM NaN3
Concentration
1 mg/ml
Shipping
Gel Pack
Storage
Store at 4°C for short term, for longer term at -20°C
Handling Advice
The antibody solution should be gently mixed before use.
Research Use Only
For research use only
Target
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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