mouse Anti-GAD1 Monoclonal Antibody (CBP6794)

Description

Synaptic signaling is the communication between cells that occurs at the synaptic level. Cells communicate with each other through direct contact (near secretory signals), short distances (paracrine signals), or long distances and scales (endocrine signals). Other cells form gap junctions, connecting their cytoplasm to The cytoplasm of adjacent cells. When the sending neuron is activated, the electrical impulse will propagate with it Axon. Once the impulse reaches the synapse, it triggers the release of neurotransmitters. The main excitatory neurotransmitter in the brain is glutamate (GLU). The inhibitory neurotransmitters GABA (in the brain) and glycine (in the brain stem and spinal cord) are common Amino acids involved in multiple metabolic cycles. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]

Epitope

Binds to an located within the peptide sequence TETDFSNLFA

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Host Species

mouse

Isotype

IgG2a

Clone Number

CBP6794

Applications

IHC; WB

Application Notes

IHC: 1:500-1:1000
WB: 1 µg/ml

Research Areas

Neurotransmitter

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

GAD1

Official Name

GAD1

Full Name

Glutamate Decarboxylase 1

Alternative Names

Glutamate Decarboxylase 1; Glutamate Decarboxylase 1 (Brain; 67kDa); Glutamate Decarboxylase 67 KDa Isoform; 7 KDa Glutamic Acid Decarboxylase; EC 4.1.1.15; GAD-67; GAD

Gene ID

2571(Human); 14415(Mouse); 24379(Rat)

Uniprot ID

Q99259(Human); P48318(Mouse); P18088(Rat)