Mouse Anti-AGER Monoclonal Antibody (CBP6818)

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. RAGE (receptor for advanced glycosylation end products), also known as AGER, is a 35 Dalton transmembrane receptor of the immunoglobulin superfamily, which was first identified by Neeper et al. in 1992. Its name stems from its ability to bind advanced glycation end products (AGE), which mainly includes glycoproteins, whose sugar groups have been non-enzymatically modified by Maillard reaction. Given its inflammatory function in innate immunity and its ability to detect a class of ligands through a common structural motif, RAGE is often called a pattern recognition receptor. RAGE also has at least one other agonistic ligand: high mobility group protein B1 (HMGB1). HMGB1 is an important intracellular DNA binding protein in chromatin remodeling. It can be passively released by necrotic cells or actively secreted by macrophages, natural killer cells and dendritic cells.

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP6818

Applications

IHC

Application Notes

IHC: 1:200-1:500

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

RAGE

Official Name

AGER

Full Name

advanced glycosylation end product-specific receptor

Alternative Names

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor; and besides AGE; interacts with other molecules implicated in homeostasis; development; and inflammation; and certain diseases; such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms; as well as non-protein-coding variants; have been described for this gene.

Gene ID

177(Human); 11596(Mouse); 81722(Rat)

Uniprot ID

Q15109(Human); Q62151(Mouse); Q63495(Rat)