NeuroMab™ Anti-RAGE BBB Shuttle Antibody(NRZP-1022-ZP2467)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

C2 domain

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; FC; IHC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease; Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

RAGE

Official Name

AGER

Full Name

advanced glycosylation end product-specific receptor

Alternative Names

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor; and besides AGE; interacts with other molecules implicated in homeostasis; development; and inflammation; and certain diseases; such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms; as well as non-protein-coding variants; have been described for this gene.

Product Pictures

ELISA

Fig.1 show ELISA binding of recombinant and hybridoma-derived anti-human RAGE monoclonal antibody to recombinant human RAGE.

Both C320-168 and C320-179 bound the longer (72-251) and shorter (84-251) isoforms of soluble, cleaved TL1a.