NeuroMab™ Anti-RAGE BBB Shuttle Antibody(NRZP-1022-ZP2465)
[CAT#: NRZP-1022-ZP2465]
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- ELISA; FC; IHC; In Vitro; In Vivo
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Immunogen
C2 domain
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Mouse
Applications
ELISA; FC; IHC; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease; Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
RAGE
Official Name
AGER
Full Name
advanced glycosylation end product-specific receptor
Alternative Names
The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor; and besides AGE; interacts with other molecules implicated in homeostasis; development; and inflammation; and certain diseases; such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms; as well as non-protein-coding variants; have been described for this gene.
Product Pictures
ELISA
Fig.1 show ELISA binding of recombinant and hybridoma-derived anti-human RAGE monoclonal antibody to recombinant human RAGE.
Both C320-168 and C320-179 bound the longer (72-251) and shorter (84-251) isoforms of soluble, cleaved TL1a.
DB
Fig.2 shows the characterization of monoclonal antibody by dot blot binding.
Both C320-168 and C320-179 bound the longer (72-251) and shorter (84-251) isoforms of soluble, cleaved TL1a.
FuncS
Fig.3 show the effect of 11E6 on the changes induced by Aβ1-40 in cerebral blood flow.
Both C320-168 and C320-179 bound the longer (72-251) and shorter (84-251) isoforms of soluble, cleaved TL1a.
FuncS
Fig.4 shows that antibody 11E6 protects hippocampal neurons against Aβ-induced dynamin cleavage.
Both C320-168 and C320-179 bound the longer (72-251) and shorter (84-251) isoforms of soluble, cleaved TL1a.
Publications
Publications (0)
Kits
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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