Mouse Anti-Human RAGE Monoclonal Antibody (CBP3726)

Product Overview

Description

RAGE (receptor for advanced glycation end products), is a member of the immunoglobulin super family of proteins with a molecular weight estimated at ~35 kD. RAGE is a pattern recognition receptor as it recognizes a common structure of a class of ligands, including HMGB1, S10012, S100B, S100A7, and amyloid precursor protein (APP). RAGE may play a role in the pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). Increased RAGE expression levels have been observed in neurons and microglia surrounding senile plaques. Besides, RAGE can mediate the transport of amyloid beta across the blood-brain barrier and its accumulation in the brain.

Immunogen

Recombinant Human RAGE

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP3726

Applications

Application Notes

WB (0.05-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Product Properties

Form

Liquid

Formulation

50% glycerol in aqueous buffered solutions with preservatives.

Concentration

0.5 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon receipt, the antibody solution should be stored undiluted at-20°C, and protected from prolonged exposure to light.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

RAGE

Official Name

AGER

Full Name

advanced glycosylation end product-specific receptor

Alternative Names

The advanced glycosylation end product (AGE) receptor encoded by this gene is a member of the immunoglobulin superfamily of cell surface receptors. It is a multiligand receptor; and besides AGE; interacts with other molecules implicated in homeostasis; development; and inflammation; and certain diseases; such as diabetes and Alzheimer's disease. Many alternatively spliced transcript variants encoding different isoforms; as well as non-protein-coding variants; have been described for this gene.