Mouse Anti-CRYAB Monoclonal Antibody (CBP6830)

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. Alpha-crystallin B chain is a protein encoded by CRYAB gene. It is part of the family of small molecule heat shock proteins and acts as a molecular chaperone, mainly binding misfolded proteins to prevent protein aggregation, and to inhibit apoptosis and promote intracellular structure. Post-translational modifications reduce the partner's ability. CRYAB mutations cause different cardiomyopathy and skeletal myopathy. In addition, the gene/protein deficiency is associated with cancer and neurodegenerative diseases (such as Alzheimer's disease and Parkinson's disease).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6830

Applications

IHC; WB

Application Notes

IHC: 1:200-1:500
WB: 1 µg/ml

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

Alpha B Crystallin

Official Name

CRYAB

Full Name

Alpha-crystallin B chain

Alternative Names

CRYAB; CMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2; crystallin alpha B

Gene ID

1410 (Human); 12955 (Mouse)

Uniprot ID

P02511 (Human); P23927 (Mouse)