Mouse Anti-AIF1 Monoclonal Antibody (CBP6835)

Description

Neuroinflammatory process is a key pathogenic factor Brain and spinal cord injury in the back. This applies not only to Acute brain injury and hypoxic-ischemic brain injury Stroke, but also used for chronic infections and neurodegenerative diseases Diseases such as Alzheimer's disease (AD), amyotrophic lateral cord Sclerosis (ALS), Lewy Body Dementia (LBD) and Multiple Sclerosis (Multiple sclerosis). In addition, local inflammation around the tumor also plays a role In the clinical progression and malignancy of glioblastoma, The most aggressive primary brain tumor. Allograft inflammatory factor 1 (AIF-1), also known as ionized calcium binding adapter molecule 1 (IBA1), is a protein encoded by the AIF1 gene in humans.

AIF1 is a protein that exists in the cytoplasm and is highly conservative in evolution. It may also be the same as the other three proteins Iba-2, MRF-1 (microglia response factor) and daintain. However, the complete functional overview of these three proteins and how they overlap are unclear. IBA1 is a 17 kDa EF hand protein that is specifically expressed in macrophages/microglia and is upregulated during the activation of these cells. Iba1 expression is up-regulated in microglia following nerve injury, central nervous system ischemia, and several other brain diseases.

Epitope

Binds to an located within the peptide sequence QFLDDPKYSSDEDLP

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP6835

Applications

IHC

Application Notes

IHC: 1:1000-1:2500

Relevant Diseases

Neuroinflammation; Neurodegenerative Disease; Alzheimer's Disease; Amyotrophic Lateral Sclerosis; Lewy body dementia

Research Areas

Neuroinflammation; Neurodegeneration

Form

Liquid

Formulation

PBS, pH 7.2, 40% glycerol

Preservatives

0.02% Sodium azide

Concentration

1 mg/ml

Purification

Protein A purified

Shipping

Gel Pack

Storage

Store at +4°C for short term storage. Long time storage is recommended at -20°C.

Handling Advice

The antibody solution should be gently mixed before use.

Research Use Only

For research use only

Target

IBA1

Official Name

AIF1

Full Name

Allograft inflammatory factor 1

Alternative Names

AIF1; AIF-1; IBA1; IRT-1; IRT1; allograft inflammatory factor 1

Gene ID

83543(Human); 108897(Mouse)

Uniprot ID

Q9BQI0(Human); Q9EQX4(Mouse)