Mouse Anti-IBA1 Monoclonal Antibody (CBP2855)

Product Overview

Description

AIF1 is constitutively expressed in monocytes and macrophages and is known to be involved in macrophage activation. It is a marker of activated macrophage. Despite a lack of detailed knowledge on the in vivo physiological functions of AIF-1, there is growing evidence that shows its aberrant expression contributes to the pathogenesis of many autoimmune diseases, including rheumatoid arthritis. (20944424). AIF1 is an actin-binding protein that enhances membrane ruffling and RAC activation. It enhances lymphocyte migration and the actin-bundling activity of LCP1. AIF1 plays a role in RAC signaling and in phagocytosis and a role in vascular inflammation. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. It is also as a microglial cell marker.

Expression Host

Mammalian cells

Immunogen

IBA1 fusion protein Ag28236

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2855

Applications

IHC; ELISA

Application Notes

IHC : 1:20-1:200

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

IBA1

Official Name

AIF1

Full Name

Allograft inflammatory factor 1

Alternative Names

AIF 1; AIF1; G1; IBA1; IRT 1; Protein G1

Gene ID

199(Human); 11629(Mouse); 29427(Rat)

Uniprot ID

P55008(Human); O70200(Mouse); P55009(Rat)

References

1. Xu, C., Diao, Y. F., Wang, J., Liang, J., Xu, H. H., Zhao, M. L.,... & Wei, M. G. (2020). Intravenously infusing the secretome of adipose-derived mesenchymal stem cells ameliorates neuroinflammation and neurological functioning after traumatic brain injury. Stem Cells and Development, 29(4), 222-234.

Publications