NeuroMab™ Anti-GluN1/NR1 glutamate receptor BBB Shuttle Antibody, Clone N308/48

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GRIN1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 42-361 (extracellular N-terminus) of rat GluN1/NR1 (also known as N-methyl-D-aspartate receptor subunit NR1, NMDAR1, NMD-R1, GRIN1, Glutamate receptor subunit zeta-1 and Glurz1, accession number P35439)
Mouse: 99% identity (319/320 amino acids identical)
Human: 99% identity (317/320 amino acids identical)
<50% identity with other Glutamate receptors

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N308/48

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GRIN1

Official Name

GRIN1

Full Name

GluN1/NR1 glutamate receptor

Alternative Names

Glutamate Ionotropic Receptor NMDA Type Subunit 1; N-Methyl-D-Aspartate Receptor Subunit NR1; Glutamate Receptor; Ionotropic; N-Methyl D-Aspartate 1; Glutamate [NMDA] Receptor Subunit Zeta-1; NMDAR1; NMD-R1; GluN1;

Uniprot ID

P35439-2

Product Pictures

Fig. 1 Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with N308/48 (left) or N52A/42 (right) TC supe.