NeuroMab™ Anti-GluN2B/NR2B glutamate receptor BBB Shuttle Antibody, Clone N59/20

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GRIN2B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 20-271 (extracellular N-terminus) of rat GluN2B/NR2B (also known as Glutamate/N-methyl D-aspartate/NMDA receptor subtype 2B or subunit epsilon 2, N-methyl-D-aspartate receptor subunit 3, NMDAR2B, NR3 and Grin2b, accession number Q00960) Mouse: 99% identity (250/252 amino acids identical)
Human: 99% identity (250/252 amino acids identical)
<50% identity with GluN2A/NR2A, GluN2C/NR2C and GluN2D/NR2D

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N59/20

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with GluN2A/NR2A, GluN2C/NR2C or GluN2D/NR2D (based on KO validation results)

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GRIN2B

Official Name

GRIN2B

Full Name

GluN2B/NR2B glutamate receptor

Alternative Names

GRIN2B; GluN2B; MRD6; NMDAR2B; NR2B; hNR3; EIEE27; glutamate ionotropic receptor NMDA type subunit 2B; NR3

Uniprot ID

Q00960

Product Pictures

Fig. 1 Cultured rat hippocampal neuron immunofluorescence.

Fig. 2 Immunoblots on brain membranes prepared from whole rat (RBM, also top right figure) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)] probed with N59/20 (left) or N52A/42 (right) TC supe.