NeuroMab™ Anti-GluN2B/NR2B glutamate receptor BBB Shuttle Antibody, Clone N59/20
[CAT#: NRZP-0423-ZP150]
- Species Reactivity:
- Rat; Mouse; Human
- Applications:
- WB; IHC; IP; ICC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GRIN2B BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 20-271 (extracellular N-terminus) of rat GluN2B/NR2B (also known as Glutamate/N-methyl D-aspartate/NMDA receptor subtype 2B or subunit epsilon 2, N-methyl-D-aspartate receptor subunit 3, NMDAR2B, NR3 and Grin2b, accession number Q00960) Mouse: 99% identity (250/252 amino acids identical)
Human: 99% identity (250/252 amino acids identical)
<50% identity with GluN2A/NR2A, GluN2C/NR2C and GluN2D/NR2D
Human: 99% identity (250/252 amino acids identical)
<50% identity with GluN2A/NR2A, GluN2C/NR2C and GluN2D/NR2D
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Rat; Mouse; Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N59/20
Applications
WB; IHC; IP; ICC
Application Notes
Does not cross-react with GluN2A/NR2A, GluN2C/NR2C or GluN2D/NR2D (based on KO validation results)
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GRIN2B
Official Name
GRIN2B
Full Name
GluN2B/NR2B glutamate receptor
Alternative Names
GRIN2B; GluN2B; MRD6; NMDAR2B; NR2B; hNR3; EIEE27; glutamate ionotropic receptor NMDA type subunit 2B; NR3
Uniprot ID
Q00960
Publications
Publications (0)
Neural Antibodies
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
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