NeuroMab™ Anti-Kv2.1 potassium channel (external) BBB Shuttle Antibody, Clone K39/25

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNB1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 211-229 (LPELQSLDEFGQSTDNPQL, extracellular S1-S2 loop) of human Kv2.1 (also known as potassium voltage-gated channel subfamily B member 1, voltage-gated potassium channel subunit Kv2.1, DRK1, accession number Q14721)
Rat: 100% identity (19/19 amino acids identical)
Mouse: 100% identity (19/19 amino acids identical)
<75% identity with Kv2.2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

K39/25

Applications

WB; IHC; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNB1

Official Name

KCNB1

Full Name

Kv2.1 K+ channel (external)

Alternative Names

KCNB1; DRK1; KV2.1; h-DRK1; EIEE26; potassium voltage-gated channel subfamily B member 1

Uniprot ID

Q14721

Product Pictures

Fig. 1 Surface immunofluorescence (no detergent permeabilization) of cultured rat hippocampal neuron transfected with HA-tagged Kv2.1 plasmid. Red = K39/25. Scale bar=20m.