NeuroMab™ Anti-Kv2.1 potassium channel subunit BBB Shuttle Antibody, Clone K89/34

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNB1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 837-853 (HMLPGGGAHGSTRDQSI, cytoplasmic Cterminus) of rat Kv2.1 (also known as Potassium voltage-gated channel subfamily B member 1, Delayed rectifier potassium channel 1, DRK1, Kcnb1 and Shab, accession number P15387)
Mouse: 100% identity (17/17 amino acids identical)
Human: 88% identity (15/17 amino acids identical, RVLPGGGAHGSTRDQSI)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K89/34

Applications

WB; IHC; IP; ICC

Application Notes

No cross-reactivity against rat Kv2.2

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNB1

Official Name

KCNB1

Full Name

Kv2.1 K+ channel

Alternative Names

KCNB1; DRK1; KV2.1; h-DRK1; EIEE26; potassium voltage-gated channel subfamily B member 1

Uniprot ID

P15387

Product Pictures

Fig. 1 Adult rat brain membrane immunoblot.

Fig. 2 Immunoblot on adult mouse brain membranes from two wild-type mice (MBM-WT) and one Kv2.1 knockout (MBM-Kv2.1-KO) mouse.

Fig. 3 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)].