NeuroMab™ Anti-Nav1.5 sodium channel BBB Shuttle Antibody, Clone N397/19
[CAT#: NRZP-0423-ZP281]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN5A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 424-658 (cytoplasmic loop between repeats I and II) of human Nav1.5 (also known as Voltage-gated sodium channel subunit alpha Nav1.5, Sodium channel protein type 5 or V subunit alpha, Sodium channel protein cardiac muscle subunit alpha, SCN5A and HH1, accession number Q14524)
Mouse: 88% identity (209/235 amino acids identical)
Rat: 87% identity (206/235 amino acids identical)
<40% identity with Nav1.1 and other Nav1 channels
Mouse: 88% identity (209/235 amino acids identical)
Rat: 87% identity (206/235 amino acids identical)
<40% identity with Nav1.1 and other Nav1 channels
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N397/19
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with Nav1.4
Research Areas
Na+ channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
SCN5A
Official Name
SCN5A
Full Name
Nav1.5 Na+ channel
Alternative Names
SCN5A; CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1; sodium voltage-gated channel alpha subunit 5
Uniprot ID
Q14524
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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