NeuroMab™ Anti-Nav1.5 sodium channel BBB Shuttle Antibody, Clone N397/19

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN5A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 424-658 (cytoplasmic loop between repeats I and II) of human Nav1.5 (also known as Voltage-gated sodium channel subunit alpha Nav1.5, Sodium channel protein type 5 or V subunit alpha, Sodium channel protein cardiac muscle subunit alpha, SCN5A and HH1, accession number Q14524)
Mouse: 88% identity (209/235 amino acids identical)
Rat: 87% identity (206/235 amino acids identical)
<40% identity with Nav1.1 and other Nav1 channels

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N397/19

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Nav1.4

Research Areas

Na+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SCN5A

Official Name

SCN5A

Full Name

Nav1.5 Na+ channel

Alternative Names

SCN5A; CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1; sodium voltage-gated channel alpha subunit 5

Uniprot ID

Q14524

Product Pictures

Fig. 1 Immunoblot against extracts of COS cells transiently transfected with untagged Nav1.4, Nav1.5 or Kv2.1 plasmid probed with N397/19 (left) or K58/35 (right) TC supe.