NeuroMab™ Anti-PlexinA1 BBB Shuttle Antibody,Clone NR3627P

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rabbit

Clone Number

NR3627P

Applications

ELISA; In Vitro; Agonist

Relevant Diseases

Multiple Sclerosis

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

PlexinA1

Official Name

PLXNA1

Full Name

Plexin-A1

Alternative Names

PLXNA1; NOV; NOVP; PLEXIN-A1; PLXN1; Plexin A1

Product Pictures

ELISA

Fig.1 illustrates plots each showing the binding activity of anti-mouse PlexinA1 antibody to mouse PlexinA1.

Sema3A(+) represents values measured with the addition of 0.8 μg/mL of mouse semaphorin 3A, and Sema3A(−) represents values measured without the addition of mouse semaphorin 3A.

Antangonist

Fig.2 illustrates a plot showing binding responses measured by immobilizing mouse chimeric antibodies hPANL#240-mFc, 359B-2-2-3-6-mFc, PXB693-mFc, PXB727-mFc, and PXB361b-mFc onto Protein G biosensors, and applying human PlexinA1 and mouse PlexinA1 thereto.

Sema3A(+) represents values measured with the addition of 0.8 μg/mL of mouse semaphorin 3A, and Sema3A(−) represents values measured without the addition of mouse semaphorin 3A.

ELISA

Fig.3 illustrates plots showing dose-dependent semaphorin 3A-like agonistic activities of anti-PlexinA1 antibodies for mouse bone marrow-derived dendritic cell contraction.

Sema3A(+) represents values measured with the addition of 0.8 μg/mL of mouse semaphorin 3A, and Sema3A(−) represents values measured without the addition of mouse semaphorin 3A.

Fig.4 illustrates a plot showing binding affinities of the agonist antibody mouse chimeras PXB693 and PXB727 for mouse PlexinA1, mouse PleixinA2, and the chimeric protein of mouse PlexinA1 and PlexinA2. 1: Mouse PlexinA1 sema domain, 2: mouse PlexinA1/A2 sema domain chimera, 3: mouse PlexinA2 sema domain, Control Ab: control antibody, PXB693: mouse chimeric antibody PXB693-mFc, PBX727-mFc: mouse chimeric antibody PXB727.

Sema3A(+) represents values measured with the addition of 0.8 μg/mL of mouse semaphorin 3A, and Sema3A(−) represents values measured without the addition of mouse semaphorin 3A.

Publications