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Creative Biolabs
Product

NeuroMab™ Anti-PlexinA1 BBB Shuttle Antibody,Clone NR1406P

[CAT#: NRZP-1022-ZP2513]

Host Species:
Chimeric
Species Reactivity:
Human; Mouse
Applications:
ELISA; In Vitro; Agonist

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Chimeric

Clone Number

NR1406P

Applications

ELISA; In Vitro; Agonist

Relevant Diseases

Multiple Sclerosis
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

PlexinA1

Official Name

PLXNA1

Full Name

Plexin-A1

Alternative Names

PLXNA1; NOV; NOVP; PLEXIN-A1; PLXN1; Plexin A1
Product Pictures
ELISA

Fig.1 illustrates a plot showing binding responses measured by immobilizing mouse chimeric antibodies hPANL#240-mFc, 359B-2-2-3-6-mFc, PXB693-mFc, PXB727-mFc, and PXB361b-mFc onto Protein G biosensors, and applying human PlexinA1 and mouse PlexinA1 thereto.

Sema3A(+) represents values measured with the addition of 0.8 μg/mL of mouse semaphorin 3A, and Sema3A(−) represents values measured without the addition of mouse semaphorin 3A.

Agonist

Fig.2 illustrates plots showing dose-dependent semaphorin 3A-like agonistic activities of anti-PlexinA1 antibodies for mouse bone marrow-derived dendritic cell contraction.

Sema3A(+) represents values measured with the addition of 0.8 μg/mL of mouse semaphorin 3A, and Sema3A(−) represents values measured without the addition of mouse semaphorin 3A.

Agonist

Fig.3 illustrates plots showing semaphorin 3A-like agonistic activities of anti-PlexinA1 antibodies against U87-MG cells.

Sema3A(+) represents values measured with the addition of 1.6 μg/mL of human semaphorin 3A.

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For Research Use Only. Not For Clinical Use.
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