NeuroMab™ Anti-PlexinA1 BBB Shuttle Antibody,Clone NR2974P

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Chimeric

Clone Number

NR2974P

Applications

ELISA; In Vitro; Agonist

Relevant Diseases

Multiple Sclerosis

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

PlexinA1

Official Name

PLXNA1

Full Name

Plexin-A1

Alternative Names

PLXNA1; NOV; NOVP; PLEXIN-A1; PLXN1; Plexin A1

Product Pictures

ELISA

Fig.1 illustrates plots each showing dose-dependent antagonistic activity of a control antibody or anti-PlexinA1 antibody (rabbit IgG) at concentrations of 0 to 100 μg/mL against semaphorin 3A-dependent mouse bone marrow-derived dendritic cell contraction.

Sema3A(+) represents values measured with the addition of 1.6 μg/mL of human semaphorin 3A.

ELISA

Fig.2 illustrates a plot showing binding responses measured by immobilizing mouse chimeric antibodies hPANL#240-mFc, 359B-2-2-3-6-mFc, PXB693-mFc, PXB727-mFc, and PXB361b-mFc onto Protein G biosensors, and applying human PlexinA1 and mouse PlexinA1 thereto.

Sema3A(+) represents values measured with the addition of 1.6 μg/mL of human semaphorin 3A.