NeuroMab™ Anti-pTau Antibody(NRP-0422-P1671)

Product Overview

Description

The humanized antibody specifically recognizes or bind phosphorylated pathological protein tau-morphs. The antibody can be used for the treatment and diagnostic use in the treatment of tauopathy, including humanized antibodies and Alzheimer's disease (AD).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Humanized

Applications

ELISA; IHC; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

pTau

Official Name

pTau

Full Name

phosphorylated tau

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40

Product Pictures

ELISA

Figure 1 shows that humanized anti-pTau antibodies hACI-36-2B6-Ab1 and hACI-36 directed against the pTau vaccine peptide (T4.5) do not bind to the non-phosphorylated version of the peptide with (T4.6) homology - 3A8-Ab1.

IHC

Figure 2 shows tau junctions in the brains of 20-month-old Tau transgenic (biGT) mice stained with the humanized anti-pTau antibody hACI-36-2B6-Ab1. Staining showing tau junctions in the cortex (A) and hippocampus (B), and degenerated staining of neural networks visible in the hippocampus (B).