NeuroMab™ Anti-TNFα Antibody(NRP-0422-P787)

Product Overview

Description

The antibody binds to human tumor necrosis factor alpha (TNF) and is useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; Cyt; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

TNFα

Official Name

TNF-α

Full Name

TNF-alpha

Alternative Names

TNF; DIF; TNF-alpha; TNFA; TNFSF2; Tumour necrosis factor; TNF-α; tumor necrosis factor; TNLG1F; Tumor necrosis factor alpha

Gene ID

7124(Human); 21926(Mouse)

Uniprot ID

P01375(Human); P06804(Mouse)

Product Pictures

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Figure 5 shows the receptor binding studies of TNF complexed with MAb 32 (—◆—), control antibody and MAb 47 (—▪—) against the melanoma cell line MM418E.

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Figure 6 shows the effect of MAb 32 (▪) control MAb and MAb 47 (*) on TNF-mediated tumor regression in vivo.

FuncS

Figure 1 shows the receptor binding studies of TNF complexed with MAb 32 (—◆—), control antibody to the melanoma cell line IGR3, and MAb 47 (—▪ ).

FuncS

Figure 2 shows the receptor binding studies of TNF complexed with MAb 32 (—◆—), control antibody and MAb 47 (—▪—) against bladder cancer cell line 5637.

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Figure 3 shows the receptor binding studies of TNF complexed with MAb 32(———), control antibody and MAb 47(—▪—) on the breast cancer cell line MCF7.

FuncS

Figure 4 shows the receptor binding studies of TNF complexed with MAb 32 (———), control antibody and MAb 47 (—570—) on the colon cancer cell line B10.

Publications