NeuroMab™ Anti-TNFα BBB Shuttle Antibody(NRZP-1022-ZP2706)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; Cyt; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

TNFα

Official Name

TNF-α

Full Name

TNF-alpha

Alternative Names

TNF; DIF; TNF-alpha; TNFA; TNFSF2; Tumour necrosis factor; TNF-α; tumor necrosis factor; TNLG1F; Tumor necrosis factor alpha

Product Pictures

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Figure 5 shows the receptor binding study of TNF complexed with MAb 32 (—◆—), control antibody, and MAb 47 (—▪—) on the melanoma cell line MM418E.

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Figure 6 shows the effect of MAb 32 (▪) control MAb and MAb 47 (*) on TNF-mediated tumor regression in vivo.

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Figure 1 shows the receptor binding study of TNF complexed with MAb 32 (—◆—), control antibody and MAb 47 (—▪ ) to the melanoma cell line IGR3.

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Figure 2 shows receptor binding studies of TNF complexed with MAb 32 (—◆—), control antibody, and MAb 47 (—▪—) on bladder cancer cell line 5637.

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Figure 3 shows the receptor binding studies of TNF complexed with MAb 32(———), control antibody and MAb 47(—▪—) on the breast cancer cell line MCF7.

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Figure 4 shows the receptor binding studies of TNF complexed with MAb 32 (———), control antibody and MAb 47 (—570—) on the colon cancer cell line B10.

Publications