NeuroMab™ Anti-TrpC7 calcium channel BBB Shuttle Antibody, Clone N64A/36

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-TRPC7 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 845-862 (FGKNLNKDHLRVNKGKDI) of human TrpC7 (also known as short transient receptor potential channel 7, capacitative calcium channel Trp7, accession number Q9HCX4)
Rat: 100% identity (18/18 amino acids identical)
Mouse: 94% identity (17/18 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N64A/36

Applications

WB; IHC; IP; ICC

Research Areas

Trp channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

TRPC7

Official Name

TRPC7

Full Name

TrpC7

Alternative Names

hTRP7; Transient receptor protein 7; TrpC7; Short transient receptor potential channel 7; TRP-7; TRP7

Uniprot ID

Q9HCX4

Product Pictures

IHC

Fig. 1 Adult rat hippocampus immunohistochemistry.

Fig. 2 Immunoblots on membranes prepared from whole mouse (MBM) and rat (RBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)], and cerebellum [HBM(Cb)].

Publications