NeuroMab™ Anti-Versican BBB Shuttle Antibody, Clone N351/24

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-versican BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 362-585 (glucosaminoglycan alpha domain) of mouse Versican core protein (also known as Chondroitin sulfate proteoglycan 2, Glial hyaluronate-binding protein, Large fibroblast proteoglycan, Vcan, Cspg2, GHAP and PG-M, accession number Q62059) Rat: 82% identity (185/224 amino acids identical)
Human: 62% identity (139/224 amino acids identical)
~50% identity with other CSPG proteins

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

N351/24

Applications

WB; IHC; ICC

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

versican

Official Name

VCAN

Full Name

Versican

Alternative Names

Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; Chondroitin sulfate proteoglycan core protein; cartilage.

Uniprot ID

Q62059

Product Pictures

Fig. 1 Adult rat brain membrane immunoblot.

Fig. 2 Immunofluorescence staining of adult spinal cord from Versican wild-type (WT) and knockout (KO) mice with N351/24 (green) and Caspr rabbit polyclonal (red).

Publications