NeuroMab™ Anti-Amyloid Beta BBB Shuttle Antibody(NRZP-1022-ZP2564)
[CAT#: NRZP-1022-ZP2564]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Cynomolgus Monkey
- Applications:
- ELISA; FC; IHC; In Vitro; In Vivo
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To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human; Cynomolgus Monkey
Clonality
Monoclonal
Host Species
Mouse
Applications
ELISA; FC; IHC; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
AmyloidBeta
Official Name
Amyloid Beta
Full Name
Amyloid Beta
Alternative Names
APP; Aβ; Abeta; Amyloid β
Product Pictures
ELISA
Fig.2 Competitive binding analysis of h3D6.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.
ELISA
Fig.5 Competitive binding analysis of h3D6.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.
ELISA
Fig.1 is a graph depicting the competition of biotinylated 3D6 against unlabeled 3D6, PK1614 and 10D5 for binding to Aβ.
h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates from PDAPP mouse brain tissue. IgG was used as a negative control in this experiment because it is unable to bind Aβ and therefore cannot induce phagocytosis.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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