NeuroMab™ Anti-HCN4 cyclic nucleotide-gated channel BBB Shuttle Antibody, Clone N114/10
[CAT#: NRZP-0423-ZP163]
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- WB; IHC; ICC
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HCN4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 1021-1110 (cytoplasmic C-terminus) of human HCN4 (also known as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, brain cyclic nucleotide-gated channel 3 and BCNG-3, accession number Q9Y3Q4)
Rat: 100% identity (90/90 amino acids identical)
Mouse: 100% identity (90/90 amino acids identical)
<50% identity with HCN1, HCN2 and HCN3
Rat: 100% identity (90/90 amino acids identical)
Mouse: 100% identity (90/90 amino acids identical)
<50% identity with HCN1, HCN2 and HCN3
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
N114/10
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with other HCN's
Research Areas
Ion channels
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
HCN4
Official Name
HCN4
Full Name
HCN4
Alternative Names
Membrane; multi pass membrane protein.
Uniprot ID
Q9Y3Q4
Publications
Publications (0)
Neural Antibodies
Neural Assays
For Research Use Only. Not For Clinical Use.
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