NeuroMab™ Anti-HCN4 cyclic nucleotide-gated channel BBB Shuttle Antibody, Clone N114/10

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HCN4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1021-1110 (cytoplasmic C-terminus) of human HCN4 (also known as potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, brain cyclic nucleotide-gated channel 3 and BCNG-3, accession number Q9Y3Q4)
Rat: 100% identity (90/90 amino acids identical)
Mouse: 100% identity (90/90 amino acids identical)
<50% identity with HCN1, HCN2 and HCN3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N114/10

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with other HCN's

Research Areas

Ion channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

HCN4

Official Name

HCN4

Full Name

HCN4

Alternative Names

Membrane; multi pass membrane protein.

Uniprot ID

Q9Y3Q4

Product Pictures

Fig. 1 Adult rat retina membrane immunoblot.

Fig. 2 Adult rat retina membrane immunofluorescence. Green = N114/10 staining of the inner nuclear, inner plexiform, ganglion cell and optic fiber layers (INL, IPL, GCL, and OFL), where layers are viewed by differential interference contrast microscopy.