Product
Mouse Anti-Rat HCN4 Monoclonal Antibody (CBP4001)
[CAT#: NAB20121010LS]
Anti-HCN4 Monoclonal Antibody
- Host Species:
- Mouse
- Species Reactivity:
- Rat
- Applications:
- WB; IHC-P
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Hyperpolarization activated cyclic nucleotide gated ion channel 4 (HCN4) is a subunit of a total 4 HCN protein family that carries inward current with the feature knows as If in the heart and Ih in the brain. Although widely expressed in the central nervous system, HCN4 is enriched in regions regulating mood and anxiety including thalamus, amygdala, midbrain dopamine system, and indirectly prefrontal cortex. SNP genotyping indicates the association of HCN4 with mood anxiety disorders. In cardiomycates, HCN4 is required for pacemaker potential generation. Mice lacking HCN4 globally or in cadiomyocytes are embryonic lethal.
Immunogen
Fusion protein corresponding to amino acids 1021-1110 (cytoplasmic C-terminus) of human HCN4
Species Reactivity
Rat
Clonality
Monoclonal
Host Species
Mouse
Isotype
IgG1, κ
Clone Number
CBP4001
Applications
WB; IHC-P
Application Notes
WB (2.5-10 µg/mL); IHC-P (5-10 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
1.0 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
References
1. Kelmendi, B. et al. 2011. Neurosci Lett. 496(3): 195-199.
2. Stieber, J. et al. 2003. Proc Natl Acad Sci U S A. 100(25):15235-40.
3. Xu, X. et al. 2010. J Biol Chem. 285(47):37082-91.
2. Stieber, J. et al. 2003. Proc Natl Acad Sci U S A. 100(25):15235-40.
3. Xu, X. et al. 2010. J Biol Chem. 285(47):37082-91.
Publications
Publications (0)
Neural Antibodies
Neural Assays
Neural Cell Lines
For Research Use Only. Not For Clinical Use.
