NeuroMab™ Anti-Homer1 BBB Shuttle Antibody, Clone L113/130

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HOMER1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 121-363 (C-terminus) of mouse Homer1L (also known as Homer protein homolog 1, VASP/Ena-related gene up-regulated during seizure and LTP 1, Vesl-1, Vesl, SYN47 and PSD-Zip45, accession number Q9Z2Y3)
Rat: 97% identity (236/243 amino acids identical)
Human: 93% identity (226/243 amino acids identical)
<30% identity with Homer1S (100% identity between amino acids 121-175, shared sequence of MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFPH)
<40% identity with Homer2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

L113/130

Applications

WB; IHC; ICC

Application Notes

Cross-reacts with Homer1S so should also react with other Homer1 isoforms

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

HOMER1

Official Name

HOMER1

Full Name

Homer1L/S

Alternative Names

Homer Scaffolding Protein 1; Homer-1; SYN47; Homer; Neuronal Immediate Early Gene; 1; Homer Homolog 1 (Drosophila); Homer Protein Homolog 1; Homer Homolog 1;

Uniprot ID

Q9Z2Y3

Product Pictures

Fig. 1 Array tomography immunofluorescence of an LRWhite-embedded 70 nm section from adult mouse cortex layer 2/3 with L113/130 (green), rabbit mAb PSD-95 and DAPI (blue), where L113/130 colocalizes with many PSD-95 puncta.