NeuroMab™ Anti-Homer1L BBB Shuttle Antibody, Clone L113/13

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-HOMER1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 121-363 (C-terminus) of mouse Homer1L (also known as Homer protein homolog 1, VASP/Ena-related gene up-regulated during seizure and LTP 1, Vesl-1, Vesl, SYN47 and PSD-Zip45, accession number Q9Z2Y3)
Rat: 97% identity (236/243 amino acids identical)
Human: 93% identity (226/243 amino acids identical)
<30% identity with Homer1S (100% identity between amino acids 121-175, shared sequence of MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFPH)
<40% identity with Homer2

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

L113/13

Applications

WB; IHC; ICC

Application Notes

Does not cross-react with Homer1S

Research Areas

Scaffolds

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

HOMER1

Official Name

HOMER1

Full Name

Homer1L

Alternative Names

Homer Scaffolding Protein 1; Homer-1; SYN47; Homer; Neuronal Immediate Early Gene; 1; Homer Homolog 1 (Drosophila); Homer Protein Homolog 1; Homer Homolog 1;

Uniprot ID

Q9Z2Y3

Product Pictures

Fig. 1 Array tomography immunofluorescence of an LRWhiteembedded 70 nm section from adult mouse cortex with L113/13 (magenta), rabbit mAb PSD-95 and Hoechst nuclear stain (blue). The insert shows three consecutive sections through the synapse that is marked with a white box.