NeuroMab™ Anti-Kir2.1 potassium channel BBB Shuttle Antibody, Clone N112B/14

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNJ2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 390-411 (cytoplasmic C-terminus) of mouse Kir2.1 (also known as Inward rectifier potassium channel 2 or subfamily J member 2, Kcnj2 and Irk1, accession number P35561)
Rat: 100% identity (22/22 amino acids identical)
Human: 90% identity (20/22 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N112B/14

Applications

WB; IHC; ICC

Application Notes

No crossreactivity against Kir2.2 or Kir2.3

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNJ2

Official Name

KCNJ2

Full Name

Kir2.1 K+ channel

Alternative Names

KCNJ2; ATFB9; HHBIRK1; HHIRK1; IRK1; KIR2.1; LQT7; SQT3; potassium voltage-gated channel subfamily J member 2; potassium inwardly rectifying channel subfamily J member 2

Uniprot ID

P35561

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with HA-tagged Kir2.1 or untagged Kv2.1 plasmids and probed with N112B/14 (left) and K89/41 (right) TC supe.