NeuroMab™ Anti-Kir2.2 potassium channel BBB Shuttle Antibody, Clone N124B/38

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-IRK-2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 390-410 (cytoplasmic C-terminus) of rat Kir2.2 (also known as ATPsensitive inward rectifier potassium channel 12 or subfamily J member 12, Kcnj12, Kcnjn1 and Irk2, accession number P52188)
Mouse: 85% identity (18/21 amino acids identical)
Human: 57% identity (15/26 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N124B/38

Applications

WB; IHC; ICC

Application Notes

No crossreactivity against Kir2.1 or Kir2.3

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

IRK-2

Official Name

KCNJ12

Full Name

Kir2.2 K+ channel

Alternative Names

Potassium Inwardly Rectifying Channel Subfamily J Member 12 ; Potassium Inwardly-Rectifying Channel; Subfamily J; Inhibitor 1 ; Potassium Voltage-Gated Channel Subfamily J Member 1 ; ATP-Sensitive Inward Rectifier Potassium Channel 1 ; Inward Rectifier K(+) Channel Kir2.2v ; KCNJN1 ; IRK- ; IRK ; Potassium Channel; Inwardly Rectifying Subfamily J; Member 1; Potassium Inwardly-Rectifying Channel; Subfamily J; Member 12 ; Potassium Channel; Inwardly Rectifying Subfamily J Member 12 ; Inward Rectifier K(+) Channel Kir2.6 ; Inward Rectifier K(+) Channel Kir2.2 ; Hkir2.2x ; Kir2.2v ; Kcnj12x ; Kir2.; HIRK1 ; HIRK ;

Uniprot ID

P52188

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with HA-tagged Kir2.2 or untagged Kv2.1 plasmids and probed with N124B/38 TC supe.

Publications