NeuroMab™ Anti-Kv3.2 potassium channel BBB Shuttle Antibody, Clone N410/17

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNC2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 474-613 (cytoplasmic C-terminus) of rat Kv3.2a (also known as Potassium voltage-gated channel subfamily C member 2, Kcnc2 and KSHIIIA, accession number P22462-3)
Human: 97% identity (137/140 amino acids identical)
Mouse: 86% identity (120/140 amino acids identical)
<50% identity with Kv3.1

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N410/17

Applications

WB; IHC; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNC2

Official Name

KCNC2

Full Name

Kv3.2 K+ channel

Alternative Names

Potassium Voltage-Gated Channel Subfamily C Member 2; Potassium Channel; Voltage Gated Shaw Related Subfamily C; Member 2; Potassium Voltage-Gated Channel; Shaw-Related Subfamily; Member 2; Voltage-Gated Potassium Channel Kv3.2; Shaw-Like Potassium Channel; KV3.2;

Uniprot ID

P22462-3

Product Pictures

Fig. 1 Immunoblot against crude membranes from adult rat brain (RBM), mouse brain (MBM) and wild-type (WT) and Kv3.2 knockout (KO) mouse brains probed with N410/17 (left) and N52A/42 (right) TC supe.