Product
NeuroMab™ Anti-PHF Tau (pS396) BBB Shuttle Antibody, Clone C8.3
[CAT#: NRZP-1022-ZP3122]
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse
- Applications:
- WB; ELISA; Inhib; In Vivo; In Vitro
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Host Species
Mouse
Clone Number
C8.3
Applications
WB; ELISA; Inhib; In Vivo; In Vitro
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
PHF Tau (pS396)
Full Name
Paired helical filament-tau
Alternative Names
PHF-Tau; MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40
Product Pictures
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Figure 1 HEK293 cells and in vitro vaccination.
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Figure 2 Depletion of tau for inoculation assay (HEK293).
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Figure 3: Inoculation experiments with depleted material (HEK293)
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Figure 4. Hippocampal tau pathology in rTg4510 mice inoculated with immunodeficient rTg4510 material.
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Figure 5. Hippocampal tangle pathology in vaccinated rTg4510 mice treated with D1.2.
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Figure 6 Tau removal (HEK293) for inoculation experiments
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Figure 7 Pathology of hippocampal tangles in rTg4510 mice inoculated with D1.2
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Figure 8 Quantification of aggregated tau after immunodeficiency reduction
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
