NeuroMab™ Anti-TREM2 Antibody(NRP-0422-P1394)

Product Overview

Description

The isolated antibody binds to a TREM2 protein, induces one or more TREM2 activities, and promotes survival of one or more innate immune cells or increases expression of IL-6.

Immunogen

Extracellular domain of TREM2, particularly the IgV domain (amino acid residues 29-112.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

Agonist; FC; In Vitro

Relevant Diseases

Alzheimer's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

TREM2

Official Name

TREM2

Full Name

Triggering receptor expressed on myeloid cells 2

Alternative Names

TREM2; Triggering receptor expressed on myeloid cells 2

Gene ID

54209(Human)

Uniprot ID

Q9NZC2(Human)

Product Pictures

FCM

Figure 1 shows protein levels of the inflammatory cytokines IL-6 and TNFα, which are secreted in response to WT, TREM2 heterozygous (Het), and TREM2 KO macrophages stimulated with the cytokines IL-4 or IFNg.

FCM

Figure 2 shows DAP12 phosphorylation measured by Western blot in wild-type and TREM2-deficient (TREM2-/-) mouse macrophages following incubation with the TREM2 antibody Ab21.

Figure 3 shows the protein levels of the inflammatory cytokines TNFa, IL-6, IL-10 and MCP-1 secreted in response to stimulation of WT and TREM2 KO macrophages with the inflammatory mediators LPS or zymosan.

Publications