NeuroMab™ Anti-TrpV1 BBB Shuttle Antibody, Clone N221/12

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VR1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-160 (cytoplasmic N-terminus) of rat TrpV1 (also known as Transient receptor potential cation channel subfamily V member 1, Osm-9-like TRP channel 1, OTRPC1, Capsaicin receptor, Vanilloid receptor 1, VR1, Vanilloid receptor type 1-like and Vr1l, accession number O35433)
Mouse: 85% identity (137/161 amino acids identical)
Human: 68% identity (110/161 amino acids identical)
<50% identity with TrpV4

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N221/12

Applications

WB; IHC; ICC

Research Areas

Trp channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

VR1

Official Name

TRPV1

Full Name

TrpV1

Alternative Names

TRPV1; VR1; transient receptor potential cation channel subfamily V member 1

Uniprot ID

O35433

Product Pictures

IHC

Fig. 1 Adult rat spinal cord immunohistochemistry.

Fig. 2 Immunofluorescence staining of adult dorsal root ganglion sections from TrpV1 WT and KO-/- mice with N221/12 TC supe (red), Kv1.2 rabbit polyclonal (green) and Hoechst nuclear stain (blue).

Fig. 3 Transfected cell immunoblot: extracts of COS-1 cells transiently transfected with HA-tagged TrpV1 or untagged Kv2.1 plasmids and probed with N221/12 (left panel) or N52A/42 (right panel) TC supe.

Publications