NeuroMab™ Anti-CALB2/calretinin BBB Shuttle Antibody, Clone L122/68

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-Calretinin BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-178 (N-terminus) of human CALB2 (also known as Calretinin, 29 kDa calbindin, CR and CAB29, accession number P22676)
Mouse: 100% identity (178/178 amino acids identical)
Rat: 100% identity (178/178 amino acids identical)
>50% identity with CALB1/calbindin

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

L122/68

Applications

WB; IHC; ICC

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

Calretinin

Official Name

CALB2

Full Name

Calretinin

Alternative Names

CALB2; CAB29; CAL2; CR; calbindin 2

Uniprot ID

P22676

Product Pictures

IHC

Fig. 1 Adult rat cortex immunohistochemistry.

Fig. 2 Array tomography immunofluorescence of a single 70 nm LRWhiteembedded section from adult mouse cortex with L122/68 (green, left), rabbit Calretinin (red, right) and DAPI (blue).