NeuroMab™ Mouse Anti-CALB2 Monoclonal Antibody (CBP2788)

Product Overview

Description

Calbindin 2 (calretinin) is an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Calretinin is a useful marker for differentiating malignant mesothelioma from carcinomas.

Expression Host

Mammalian cells

Immunogen

Calretinin fusion protein Ag2924

Species Reactivity

Human; Mouse; Porcine; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2788

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Metabolism

Conjugation

Unconjugated; APC; PE; HRP; Biotin; FITC; Alexa Fluor 488; Alexa Fluor 700; Alexa Fluor 647; Alexa Fluor 750; Alexa Fluor 594; Alexa Fluor 350; Alexa Fluor 1894

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Endotoxin Level

Low Endotoxin

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Calretinin

Official Name

CALB2

Full Name

Calbindin 2

Alternative Names

29 kDa calbindin; CAB29; CAL2; CALB2; calbindin 2; Calretinin; CR

Gene ID

794(Human); 12308(Mouse); 117059(Rat)

Uniprot ID

P22676(Human); Q08331(Mouse); P47728(Rat)

References

1. Sano, H., Namekata, K., Kimura, A., Shitara, H., Guo, X., Harada, C.,... & Harada, T. (2019). Differential effects of N-acetylcysteine on retinal degeneration in two mouse models of normal tension glaucoma. Cell death & disease, 10(2), 1-14. 2. Akaiwa, K., Namekata, K., Azuchi, Y., Sano, H., Guo, X., Kimura, A.,... & Harada, T. (2018). Topical ripasudil suppresses retinal ganglion cell death in a mouse model of normal tension glaucoma. Investigative Ophthalmology & Visual Science, 59(5), 2080-2089. 3. Zhou, H., Su, J., Hu, X., Zhou, C., Li, H., Chen, Z.,... & Zhou, Y. (2020). Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice. Cell.

Publications