Mouse Anti-Calretinin Monoclonal Antibody (CBP4293)

Product Overview

Description

Calretinin is a calcium-binding protein that is abundantly expressed in interneurons and multiple regions of the brain, including the brainstem, hypothalamus, hippocampus, and cerebellum. Calretinin is involved in regulating intracellular calcium signaling and modulating neuronal excitability. Loss and reorganization of calretinin-positive interneurons have been indicated as possible cause in human epilepsy. In addition, calretinin is considered as the most sensitive and specific marker for the diagnosis of malignant mesothelioma.

Immunogen

Recombinant human CALB2

Species Reactivity

Human; Rat

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b, κ

Clone Number

CBP4293

Applications

Application Notes

WB (0.1-2.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.