NeuroMab™ Anti-KCNQ1 potassium channel BBB Shuttle Antibody, Clone N37A/10

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNQ1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 2-101 of human KCNQ1 (Kv7.1, KvLQT1, accession number P51787)
Rat: 72% identity (71/98 amino acids identical)
Mouse: 63% identity (62/98 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N37A/10

Applications

WB; IHC; IP; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNQ1

Official Name

KCNQ1

Full Name

Kv7.1/KCNQ1 K+ channel

Alternative Names

Potassium Voltage-Gated Channel Subfamily Q Member 1; IKs Producing Slow Voltage-Gated Potassium Channel Subunit Alpha KvLQT1; Potassium Channel; Voltage Gated KQT-Like Subfamily Q; Member 1; Potassium Voltage-Gated Channel; KQT-Like Subfamily; Member 1; Voltage-Gated Potassium Channel Subunit Kv7.1; KVLQT1; KCNA8; KCNA9; Potassium Voltage-Gated Channel Subfamily KQT Member 1; Kidney And Cardiac Voltage Dependend K+ Channel; Slow Delayed Rectifier Channel Subunit; Jervell And Lange-Nielsen Syndrome 1;

Uniprot ID

P51787

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM (left lane) and COS-1 cells transiently transfected with flag-tagged KCNQ1 (middle lane) or Kv2.1 (right lane) plasmids and probed with pure N37A/10 (left panel), rabbit anti-flag (middle panel) or K89/41 TC supe (right panel).