NeuroMab™ Anti-KCNQ2 potassium channel BBB Shuttle Antibody, Clone N26A/23

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-KCNQ2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1-59 (cytoplasmic N-terminus) of human KCNQ2 (also known as Potassium voltage-gated channel subfamily KQT member 2 or KvLQT2, Kv7.2 and KQT-like 2, accession number O43526)
Rat: 96% identity (56/58 amino acids identical)
Mouse: 96% identity (56/58 amino acids identical)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N26A/23

Applications

WB; IHC; ICC

Research Areas

K+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

KCNQ2

Official Name

KCNQ2

Full Name

Kv7.2/KCNQ2 K+ channel

Alternative Names

KCNQ2; BFNC; BFNS1; EBN; EBN1; EIEE7; ENB1; HNSPC; KCNA11; KV7.2; KVEBN1; potassium voltage-gated channel subfamily Q member 2

Uniprot ID

O43526

Product Pictures

Fig. 1 Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS-1 cells transiently transfected with KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 or Kv2.1 plasmids and probed with pure N26A/23.

Publications