NeuroMab™ Anti-LAG3 Antibody(NRP-0422-P1635)
[CAT#: NRP-0422-P1635]
Functional antibody against Human LAG3
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- ELISA; Inhib; In Vitro
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The antibody is a potent and selective binder for D1 and D2 domain of human LAG3.
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Humanized
Applications
ELISA; Inhib; In Vitro
Application Notes
CSF1R
Relevant Diseases
Parkinson's Disease
Product Properties
Formulation
PBS only
Preservatives
BSA Free
Concentration
1mg/mL
Purification
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purity
> 95% (SDS-PAGE)
Endotoxin Level
Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg
Low Endotoxin < 1 EU/mg
Shipping
Gel Packs
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Research Use Only
For research use only
Target
Product Pictures
ELISA
Figure 1 ELISA results showing EC50 of antibody binding to LAG3 intact extracellular domain (D1-D4 huFc) but not D1-D2 deleted LAG3 (△D1-D2 huFc).
Inhib
Figure 2 Dose-dependent inhibition of the binding of LAG3 to its receptor MHC class II molecules.
FuncS
Figure 3 122H, 147H, and 170H mouse mAbs dose-dependently promote IL2 production by Jurkat T cells.
FuncS
Figure 4 Humanized monoclonal antibody 147H-13 dose-dependently promotes the production of IL2 by Jurkat T cells.
FuncS
Figure 5 Effect of affinity matured anti-LAG3 antibody on stimulation of IL2 release from Jurkat T cells.
Block
Figure 6 Anti-LAG3 antibody blocks the binding of Galectin-3 or LSECtin to LAG3.
Block
Figure 7 The combination of anti-LAG3 antibody and anti-PD-L1 antibody produced significantly more IL-2 than each alone.
Block
Figure 8 Combination of anti-PD-L1 antibody and 147H-13 shows strong inhibition of MC38 tumor growth.
Publications
Publications (0)
Neural Antibodies
Kits
For Research Use Only. Not For Clinical Use.
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