NeuroMab™ Anti-Nav1.1 sodium channel BBB Shuttle Antibody, Clone K74/71

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-SCN1A BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1929-2009 (cytoplasmic C-terminus, HLLKRTVKQASFTY NKNKLKGGANLLVKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEK HEQEGKDEKAKGK) of rat Voltage-gated sodium channel subunit alpha Nav1.1 (also known as Sodium channel protein type 1 subunit alpha, Sodium channel protein brain I subunit alpha, Scn1a, NAC1 and SCN1, accession number P04774)
Mouse: 98% identity (80/81 amino acids identical)
Human: 97% identity (79/81 amino acids identical)
~50% identity with Nav1.2 and Nav1.3

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse; Human

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K74/71

Applications

WB; IHC; IP; ICC

Application Notes

Does not cross-react with Nav1.2 or Nav1.3

Research Areas

Na+ channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

SCN1A

Official Name

SCN1A

Full Name

Nav1.1 Na+ channel

Alternative Names

Sodium Voltage-Gated Channel Alpha Subunit 1; Sodium Channel; Voltage-Gated; Type I; Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.1; Sodium Channel Protein Type I Subunit Alpha; SCN1; NAC1; Sodium Channel; Voltage-Gated; Type I; Alpha Polypeptide; Sodium Channel; Voltage Gated; Type I Alpha Subunit; Sodium Channel Voltage Gated Type 1 Alpha Subunit; Sodium Channel Protein; Brain I Alpha Subunit; Sodium Channel Protein Brain I Subunit Alpha;