NeuroMab™ Anti-NOTCH3 Antibody(NRP-0422-P1846)
Functional antibody against Human Notch3
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- WB; ELISA; FC; Cyt; In Vitro; In Vivo
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Lot Number
SPECIFIC INQUIRY
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Immunogen
Species Reactivity
Clonality
Host Species
Applications
Relevant Diseases
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
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Research Use Only
Target
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Alternative Names
Figure 1 shows Western blot analysis of Notch3 positive and negative cell lines using the D11B8 antibody.
Figure 2 Intracellular trafficking of anti-Notch3 antibody hu75-Alexa 488 and co-localization with pHrodo™ red dextran in MDA-MB-468 breast cancer cells at 5 hours (arrow), [C] anti-Notch3 antibody hu28- Cell membrane localization of DyLight650 and labeling of acidic vesicles in MDA-MB-468 breast cancer cells with pHrodo™ red dextran (intracellular spots) at hour 0, [D] intracellular trafficking of the anti-Notch3 antibody hu28-DyLight650 and association with Co-localization of pHrodo™ red dextran in MDA-MB-468 breast cancer cells at 8 hours (arrows) and [E] Pearson correlation coefficient indicating that hu28-DyLight650 and pHrodo™ red dextran fluorescently labeled in MDA-MB Overlap or colocalization degree time in -468 cells.
Figure 3 shows Western blot analysis of the S2 cleavage assay using anti-Notch3 hu28 and hu75 treated HCC2429 and MDA-MB-468 cells. MW = molecular weight.
Figure 4 shows that treatment of OVCAR3 ovarian cancer cells with anti-Notch3 hu28-vc0101 disrupts microtubules in mitotic cells (stained with anti-α-tubulin antibody), identified by phospho-histone H3 staining.
Figure 5 shows Western blot analysis of Notch3-ECD from xenografts harvested from 2-3 mice (M).
Figure 6 shows the efficacy of anti-Notch3 hu28-vc0101 and hu75-vc0101 at a dose of 3 mg/kg compared to cisplatin at a dose of 5 mg/kg in a 37622A1 NSCLC patient-derived xenograft model.
Figure 7 shows the efficacy of anti-Notch3 hu28-vc0101 in the MDA-MB-468 breast model.
Figure 8 shows the efficacy of anti-Notch3 hu28-vc6780 in the MDA-MB-468 breast model.
Figure 9 shows the efficacy of anti-Notch3 hu28-vc0101 in the OVCAR3 ovarian model.
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