NeuroMab™ Anti-VMAT1 BBB Shuttle Antibody, Clone N440/61
[CAT#: NRZP-0423-ZP468]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC
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Lot Number
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Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-VMAT1 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 43-135 (first lumenal domain) of mouse Slc18a1 (also known as Solute carrier family 18 member 1, Vesicular amine transporter 1, Chromaffin granule amine transporter, VAT1, VMAT1 and Cgat, accession number Q8R090)
Rat: 92% identity (86/93 amino acids identical)
Human: 65% identity (62/96 amino acids identical)
<30% identity with Slc18a2/VMAT2
Rat: 92% identity (86/93 amino acids identical)
Human: 65% identity (62/96 amino acids identical)
<30% identity with Slc18a2/VMAT2
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N440/61
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with VMAT2
Research Areas
Transporters
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
VMAT1
Official Name
SLC18A1
Full Name
VMAT1
Alternative Names
Solute Carrier Family 18 (Vesicular Monoamine); Member 1
Uniprot ID
Q8R090
Product Pictures
IHC
Fig. 1 Adult rat brain immunohistochemistry.
IB
Fig. 2 Adult rat brain membrane immunoblot.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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