NeuroMab™ Anti-GFAP BBB Shuttle Antibody, Clone N206A/8

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GFAP BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Synthetic peptide amino acids 411-422 (KTVEMRDGEVIK) of human GFAP (also known as Glial fibrillary acidic protein, accession number P14136)
Rat: 100% identity (12/12 amino acids identical)
Mouse: 100% identity (12/12 amino acids identical)
>50% identity with other proteins (Vimentin, Desmin, Tumor protein p73 and Peripherin)

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N206A/8

Applications

WB; IHC; ICC

Application Notes

Cross-reacts with GFAP-R416W and other GFAP mutant proteins;Does not cross-react with other proteins (based on KO validation results)

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GFAP

Official Name

GFAP

Full Name

GFAP

Alternative Names

Glial Fibrillary Acidic Protein; Intermediate Filament Protein; ALXDRD;

Uniprot ID

P14136

Product Pictures

Fig. 1 Immunoblot versus low speed pellet samples from rat brain (RBLSP) and wild-type (WT), GFAP knockout (KO) and GFAP-R416W mutant knockin (KI) mice and probed with N206A/8 (left), mutant control(middle) and N52A/42 (right).