NeuroMab™ Anti-Notch2/3 BBB Shuttle Antibody(NRZP-1022-ZP3235)

Figure 1: FACS analysis of the cross-reactivity of the 59R1 IgG2 antibody with four human Notch homologues. 59R1 was found to bind hNotch2 and hNotch3 on transiently transfected HEK-293 cells, but no significant binding was found to hNotch1 and hNotch4 on the same cells.

Figure 2: Anti-Notch2/3 antibody 59R1 inhibits Notch2 signaling in a luciferase reporter assay.

59R1 blocks hDLL4-induced Notch2 reporter activity.

Figure 3 Notch2/3 receptor antibody 59R1 inhibits tumor formation and growth in vivo.

Anti-Notch2/3 (59R1) Inhibits the Formation of PE13 Breast Tumors.

Figure 4: Anti-Notch2/3 antibody 59R1 delays recurrence of B51 breast tumors after paclitaxel treatment.

Figure 5: Anti-Notch2/3 antibody 59R1 reduces cancer stem cell frequency in B51 breast tumors.

Figure 6: Anti-Notch2/3 antibody 59R1 inhibits the growth of PN4 pancreatic tumors in combination with gemcitabine.

Figure 7: Anti-Notch2/3 antibody 59R1 inhibits tumor growth in an M4 melanoma xenograft model.

Figure 8: Anti-Notch2/3 antibody 59R1 inhibits the growth of C28 colon tumors alone and in combination with irinotecan.

Figure 9: 59R1 IgG2 antibody significantly inhibits tumor growth of established human tumor xenografts in vivo.