NeuroMab™ Anti-TrpM7 ion channel and Ser/Thr kinase BBB Shuttle Antibody, Clone N74/25

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-TRPM7 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 1817-1863 (cytoplasmic C-terminus) of mouse TrpM7 (also known as transient receptor potential cation channel subfamily M member 7, long transient receptor potential channel 7, LTrpC7, channel-kinase 1 and TRP-PLIK, accession number Q923J1) Rat: 97% identity (46/47 amino acids identical)
Human: 93% identity (44/47 amino acids identical)
<30% identity with TrpM6

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N74/25

Applications

WB; IHC; ICC

Application Notes

No cross-reactivity with TrpM6

Research Areas

Trp channels

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

TRPM7

Official Name

TRPM7

Full Name

TrpM7

Alternative Names

Transient Receptor Potential Cation Channel Subfamily M Member 7; Long Transient Receptor Potential Channel 7; Channel-Kinase 1; EC 2.7.11.1; LTrpC-7; LTRPC7; CHAK1;

Uniprot ID

Q923J1

Product Pictures

Fig. 1 Immunoblot against adult rat brain membrane (RBM), rat liver membrane (RLM) and extracts of COS cells transiently transfected with TrpM6, TrpM7 or Kv2.1 plasmid probed with N74/25 (left) or a loading control (right) TC supe.

Publications