Mouse Anti-NR1H2 Monoclonal Antibody (CBP2675)

Name: Mouse Anti-NR1H2 Monoclonal Antibody (CBP2675)
SKU: NAB20101749CR
Rating: 5 (1 reviews)

[CAT#: NAB20101749CR]

Mouse Monoclonal (1E12B10) to NR1H2

Host Species:: Mouse

Species Reactivity:: Human; Porcine

Applications:: WB; ELISA

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Product Overview

Description

NR1H2 is a liver X receptors, which form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. It preferentially bind to double-stranded oligonucleotide direct repeats, which have the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). It involves in the regulation of cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.

Expression Host

Mammalian cells

Immunogen

NR1H2 fusion protein Ag5635

Species Reactivity

Human; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1

Clone Number

CBP2675

Applications

WB; ELISA

Application Notes

WB : 1:500-1:1000

Research Areas

Neural Signal Transduction

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1000 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

NR1H2

Official Name

NR1H2

Full Name

Nuclear receptor subfamily 1, group H, member 2

Alternative Names

Liver X receptor beta; LXR b; LXRB; NER; NER I; NR1H2; Nuclear receptor NER; Oxysterols receptor LXR beta; RIP15; UNR

Gene ID

7376(Human); 22260(Mouse); 58851(Rat)

Uniprot ID

P55055(Human); Q60644(Mouse); Q62755(Rat)

References

1. Guo, F., Hong, W., Yang, M., Xu, D., Bai, Q., Li, X., & Chen, Z. (2018). Upregulation of 24 (R/S), 25-epoxycholesterol and 27-hydroxycholesterol suppresses the proliferation and migration of gastric cancer cells. Biochemical and biophysical research communications, 504(4), 892-898. 2. Wang, X., Zhao, H., Yan, W., Liu, Y., Yin, T., Wang, S.,... & Tao, L. (2019). Thioredoxin-1 promotes macrophage reverse cholesterol transport and protects liver from steatosis. Biochemical and biophysical research communications, 516(4), 1103-1109.

Publications